Too many differential peaks derived from FindMarkers() [Signac]
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20 months ago

I am currently conducting scATAC-seq downstream analysis and just ran FindMarkers() comparing two biological conditions. In all, the number of diff. peaks turned out as ~5,000 which is rather high (the expected is around 500). How would I go about this? Should I intersect this with DEGs from an RNA experiment, etc.

**Yes, I have used the default parameters from Signac's FindMarkers() function.

Signac ATAC scATAC-seq • 506 views
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