PRSice-2 using SNPs with extremely low P-value

Question

[Apprentice]

I would like to construct a Polygenic risk score using PRSice-2. However, our summary statistics contains a very small P-value, such as P-value=5.0x10^-1200. Perhaps that is why we cannot use this summary statistics to construct the PRS. How can I solve this problem? I would be grateful if you could enlighten me.

Answer 1

[Apprentice]

I had asked the same question on PRSice's git hub. I got an answer from the developer and will share it here as well. https://github.com/choishingwan/PRSice/issues/320