Entering edit mode
18 months ago
rheab1230
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140
Hello everyone, I have a HiC data which has chromosomal interaction. But this dataset has chr20 region interacting with chr20 region. I want to look for datasets that have inter chromosomal interactions. like chr20 region interactin with chr2 region. Is there any mechanism to explain these interactions between different chromosomes? Mainly enhancer regulator interactions is only chromosome wise. Or transcription factor also regulates same chromosomes genes Thank you.
I don't think it is possible. HiC resolution is limited even for intra-chromosome interactions, and most bioinformatic tools discard reads mapping discordantly to more than one chromosome.
apart from tool, is there any biological mechanism for explanation of interactions between different chromosomes?