Reference Panel for Copy Number Analysis Based on Clinical Target Capture Sequencing

Question

[Noushin N]

Hi everyone,

I am starting on a project that involves somatic copy number analysis of tumor tissue profiled by clinical grade target capture sequencing (FoundationOne).

Typically, we would use matched normal samples from each individual to alleviate issues including non-uniformity of coverage across the genome due to the capture process. But the current dataset does not include matched normals.'

I was wondering if you have any ideas on how to locate targeted NGS data for (unmatched normal) samples in general, or any other workaround approaches.

Thank you!