Hi all,
The Encode website offers relaxed, conservative and optimal narrowPeak ChIP-seq transcription-factor datasets.
However, for histone marks, relaxed, replicated, and pseudoreplicated datasets are offered instead.
I understand that the replicated and pseudoreplicated datasets are more or less equivalent to the conservative datasets. Are optimal datasets available for histone marks? Some histone mark datasets are labelled as pseudoreplicated and have two isogenic replicates (see https://www.encodeproject.org/experiments/ENCSR000AKE/ for an example)...to me, these could be optimal datasets. Please could someone confirm?