GERP Score for variants

Question

[adarsh]

Hello,

I need to find GERP score for some variants. Other than the normal annotation pipeline, is there any online web based tool to calculate this score?

Please suggest.

Thanks

Answer 1

[Prash]

Dear Adarsh, Varsome and Mastermnd Genomebase does that: https://varsome.com/

For multiple or bulk queries, you may have to download GERP scores for all positions and awk/grep and find them: http://mendel.stanford.edu/SidowLab/downloads/gerp/

Best, prash

[adarsh]

Thank you so much for the reply. In VarSome, there are scores from multiple platforms except GERP.

However, I was able to get the GERP++ scores through online VEP, which has annotations from dbNSFP.

[Begonia_pavonina]

It seems that the link http://mendel.stanford.edu/SidowLab/downloads/gerp/ is dead now. Would anyone know if it is temporary of definitive? I have a lot of trouble to find any documentation on GERP++.