Protein chains vs protein Interactions

Question

[hpoddar2810]

Hi,

I recently started working on a project where I need to understand protein-protein interactions. I want to understand the difference between two protein chains vs. protein-protein interaction complexes. From my noob understanding, two chains can also considered as two proteins interacting.

[Pierre Lindenbaum]

how is it related to bioinformatics ?

Answer 1

[bhumm]

I'm not sure I completely understand what you are asking for. As @Jeremy stated, multiple peptide chains can make up a singular protein (e.g., heavy and light chains in antibodies), whereas protein-protein interactions are composed of distinct proteins. If you are trying to visualize or calculate protein-protein interactions, you can use tools like GROMACS (https://www.gromacs.org/index.html).

Answer 2

[Jeremy]

Multiple peptide chains can be linked together to create a single protein, whereas a protein-protein interaction would require multiple proteins (AKA polypeptides if they are composed of more than one chain).