PLINK format file for BOLT-LMM
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18 months ago
Apprentice ▴ 170

I would like to perform BOLT-LMM to assess the association of SNP with a quantitative trait. BOLT-LMM requires PLINK format files (bed, bim, fam) and imputed files (bgen, sample). Should I use direct genotype data typed from SNP arrays for the plink format files? Or should I use the imputed genotype data converted to plink format?

Also, do PLINK format files require quality control (e.g., removal of SNPs with MAF<0.01)? Please let us know.

BOLT-LMM SNP • 416 views
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