Bulk and Single cell TCRSeq analysis

Question

[synat.keam]

Dear All,

I am engaging in bulk and single cell TCR Seq for my postdoc research project. I am wondering whether our members here could point me to vignette including starting from alignment tool, softwares required for alignment, setup, data preprocessing, cleaning and actual analysis. Really appreciate if you could help. Looking forward to hearing from you soon. Have a good day!

Kind Regards,
Synat

Answer 1

[bk11]

I had a lot of success with MiXCR before with both bulk and single cell TCR analysis.

https://mixcr.com/mixcr/reference/overview-analysis-overview/

Answer 2

[Ming Tommy Tang]

see a bunch of resources here https://github.com/crazyhottommy/TCR-BCR-seq-analysis