Entering edit mode
15 months ago
Chris
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340
Hi all,
This github page mention a kind of interesting analysis call centrality analysis which I try to find and found one in this paper but not sure.
https://github.com/quadbio/scMultiome_analysis_vignette/blob/main/Tutorial.md.
https://www.nature.com/articles/s41467-022-31960-7#Sec12. In this paper they call Transcriptional regulatory network analysis.
Would you recommend a tutorial or papers do centrality analysis which mention in the end of the github page? Thank you so much!
Centrality is a measument you can perform on networks (you can read more about it here). So in order to perform a centrality analysis, you need to construct a gene regulatory network. It seems that the first link you provide already shows you how to do it :)
Thank you so much! So after building a gene regulatory network, what is the next step to do centrality analysis? The way the author of the GitHub page said it made me think he mentioned something beyond what he did in the end.
I would recommend reading through this paper to understand more what follows after the construction of the networks .
What did the author mention? In what context? And with what details? You need to be specific in order to elicit help from readers.
The author said that: "There are much more analysis, particularly those graph-based analysis, that can be done to the GRN, such as centrality analysis to identify TFs which may trigger huge regulatory cascades." , in the context of single cell multiome analysis, gene regulatory network reconstruction (the last section). Hope it can give you a better view for the question.