How to interpret the Variant Allele Frequency??

Question

[hashim.rana11]

I am new to the field of Bioinformatics and seeking guidance. I am currently in the process of calculating the Variant Allele Frequency (VAF) using the VarScan software. I have obtained the results and have included screenshots for reference. I would greatly appreciate assistance in understanding how to interpret these results.

These are the Headings of the result

CHROM   POS ID  REF ALT QUAL    FILTER  INFO    FORMAT  Sample1

Answer 1

[DareDevil]

Variant allele frequency (VAF) = Depth at Altered Allele / Total Depth

Total depth = Depth at Altered Allele + Depth at Reference Allele

Answer 2

[Pierre Lindenbaum]

How to interpret variant allele frequency?