SPOTlight error with Visium data

Question

[Hien]

Hi, could anyone help to fix the error with SPOTlight command?

I have one reference from single cell experiment (cortex_sc) and one data from h5 file with Visium Spatial transcriptome. I have the gene markers based on clusters from cortex_sc with the tutorial from SPOTlight. Therefore, I would like to see the gene-cell regulation via SPOTlight. The command as:

set.seed(687)

res1 <- SPOTlight(
    x = cortex_sc,
    y = data_sc,
    groups = as.character(cortex_sc$category),
    mgs = cluster_markers_all,
hvg = NULL,
    weight_id = "avg_log2FC",
    group_id = "cluster",
    gene_id = "gene"
)

It shows:

Scaling count matrix
Seeding initial matrices
Training NMF model
Error in cons != .consold : non-conformable arrays
In addition: Warning message:
In asMethod(object) :
  sparse->dense coercion: allocating vector of size 1.5 GiB
Timing stopped at: 0.12 0.04 0.17

Could anyone suggest solutions to fix it? Thank you!