DepMap Portal

Question

[roya.solhi]

Hi, everyone, When I searched a gene in DepMap portal, in the "Top Co-dependencies CRISPR (DepMap Public 23Q2+Score, Chronos)" section, there is a 100-gene list with a correlation score. Do you know what that score means? And how we interpret the results of this section? Thank you

Answer 1

[jared.andrews07]

It's just the pearson correlation between the CRISPR dependency scores for the genes across all lines. For example, BRAF is listed as a co-dependency of SOX10 (correlation of 0.57), and this is what plotting each of their scores looks like:

A positive value indicates that the scores tend to increase together. A negative score would indicate that the genes are opposing, e.g. one scoring highly in a sample means the other tends to score lowly in the same sample.

[roya.solhi]

Thank you Jared.Andrews for your answer, Yes, you are right; the top co-dependencies, whose dependency scores are highly correlated with that of the query gene.