Calculating height prediction from PGS

Question

[fitwae]

Hi, I'm trying to get height prediction values from Yengo 2022 paper (https://www.nature.com/articles/s41586-022-05275-y). I downloaded the PGS weights from https://www.joelhirschhornlab.org/giant-consortium-results, which has SNPs and their weights. But, I don't see any formula to derived predicted heights with these weights. Anyone could illuminate on this?

[barslmn]

This is the paper if you want to do PRS analysis: https://www.nature.com/articles/s41596-020-0353-1

[fitwae]

Thanks. I'll check it out.

Answer 1

[Sam]

You don't really get a "predicted" height per-sec, rather, you get a score that has correlates with the height. With the provided weights, you can directly use plink --score to generate the polygenic score, but most likely they won't look like height (e.g. mean 170 in male and 160 in female etc).

[fitwae]

Thanks. Is it linear, as in height = score * (some factor) + (some factor)?