Is it valuable to identify hubgenes of miRNAs target genes

Question

[Ant]

Hello,

I am studying differentially expressed miRNAs of a disease. The work is in bioinformatics and I thought about doing a HUB GENES analysis for the genes that the selected myrnas are targets, in addition to the PPI analysis, but looking at the literature I just didn't find this type of approach. Do you think it is an interesting analysis(HUBgenes) to do or does it not make sense?

Answer 1

[Trivas]

Are you asking whether a miRNA targets multiple proteins within the same pathway? You could use a target prediction software (miRDB) and perform GO analysis with your hits.

[Ant]

Sorry, english is not my first language, I didn't explain it well. I want to know if it makes sense to do a hub gene analysis of the predicted targets of the mirnas.