Hello Biostar community,
I hope you're all doing well.
I'm currently conducting research where we've observed cell death following treatment with a specific drug. However, we're still in the dark about the underlying mechanism, and we suspect it might be connected to the drug binding to the glucocorticoid receptor (GR).
I have access to the expression levels of genes in both a Control group and a group Treated with the drug. My objective is to determine if the genes that are overexpressed in the drug-treated group are indeed linked to the glucocorticoid receptor.
Unfortunately, I've been struggling to find a resource that provides a comprehensive list of genes involved in this process. Many papers I've come across mix different genes, making it challenging to isolate the relevant information. I've attempted to use databases like Reactome and KEGG, but I haven't been able to locate specific information about the glucocorticoid receptor. While there are some general Gene Ontology (GO) terms related to corticosteroid and steroid biosynthesis, these are not precisely what I need. My main goal is to determine whether this drug is binding to the receptor and subsequently activating genes within this pathway.
Does anyone here know of a webpage or resource where I can find a comprehensive list of genes known to interact with the glucocorticoid receptor (GR)?
I would greatly appreciate any recommendations or insights you can provide. Your assistance would be invaluable to my research.
Thank you in advance for your help.
Best regards,
Hello,
Have you checked out STRING yet? It enters your identifier and provides you with the interactors of your protein based on co-expression and experimental validations.
Link:
https://string-db.org/cgi/input?sessionId=b1GUH157jMKR&input_page_show_search=on