How to normalize for Correlation network with two different parameters
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12 months ago
Mary • 0

Hi all!

From the article (https://doi.org/10.1007%2Fs11684-022-0921-6), I am specifically referring to figure 3 A & C that describes "Analysis of the correlation between severity-related gut microbes and markers associated with organ damage or dysfunction". In this plot, the authors have taken pathogens (their reads /counts) against clinical parameters (numerical values).

Pasted figure too for reference. enter image description hereenter image description here

That's such a good approach. Though I wanted to know how we could compare clinical parameters with different units together against pathogens (read/counts).

What normalization method should be used for normalizing values of clinical parameters?

My interest is to do correlation between a set of dengue infected host genes (my dataset) against clinical parameters of my cohort.

Thanks!

Correlation Normalization • 340 views
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