Entering edit mode
11 months ago
ccagg
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60
Is there a way to do a recessive model in the R package SAIGE for a GWAS? For example, in PLINK you might specify:
plink2 --bfile <input file> -pheno <pheno file> --glm recessive --out <output>
I have seen some papers referencing using SAIGE with a recessive instead of additive model (ex: DOI:10.1038/s41586-022-05420-7), but it is not clear to me how to do this reading the most recent SAIGE documentation