Perform mean imputation

Question

[Patrick]

I have 2 vcf files, one large one with samples from a lot of individuals and one vcf file with only 1 sample.

Is there a way to impute the missing genotypes in the small vcf by choosing the mean genotype in that sample from the large vcf file? In the end both samples should have similar amounts of variants in them.

Is this something you can do and if so how?

Thanks for any reply.