eQTL analysis using GWAS summary statistics only

Question

[Sebastian]

Hello,

I'm doing some research in bladder cancer and i have a dataset of genotyped data so i have GWAS summary statistics from 2 GWAS. I would like to know if there is a way to do an eQTL analysis using only the data that i have (i have not expression data). I don't know if that's possible using data from the GTEx project, or any other public data.

If it's possible, can you tell me how? or send me some papers, packages, tutorials?

thanks a lot.

Answer 1

[LChart]

It should be clear that the identification of eQTLs is impossible without genotypes and gene expression measured in the same individuals. I also suspect this is not what you had in mind. Please take a look at colocalization, and TWAS as these may be closer to what you had in mind.