Mutual information method for gene markers identification ???

Question

[Ondina]

Hello everyone,

I'm searching for an R or Python package which would allow an efficient gene marker selection with the usage of Mutual Information. The idea is to compare and mix the results of this technique with the results of my differential gene expression analysis of my single-cell RNA-seq data (classical FindMarkers output).

I've already found this code which was quite interesting https://github.com/felixhorns/FlyPN/blob/master/analysis/ICIM_Example.ipynb but I can't manage to import the ICIM class from the sct module.

So does someone has any idea on how to do mutual information analysis on scRNA-seq data?

Thank you!