Hello everyone,
I have some Bionano data which says that a deletion is causing a PAX5::ZCCHC7 gene fusion. We have some RNASeq data processed with STAR fusion data saying there is 1921 supporting reads for this gene fusion. However, how can a deletion cause this fusion when the two genes are on opposite strands? An inversion could cause this, but a deletion causing this makes no sense. Am I missing something here?
your previous questions have answers that should be validated: Noisy germline CNV data using CNVKit ; Does the GENOtation web-based PCA tool work? ;