What tools exist for filtering hundreds of VCFs (and annotated into VCFs in txt format) with GUI?
1
0
Entering edit mode
10 months ago
iarmir ▴ 10

I emphasize: hundreds. There is a good cutevariant tool, but it is suitable for a single file. VarAFT has a lot of bugs. VCF-Miner possibly good, but I didn't use it because of troubles with docker (permission denied).

VarAFT VCF-miner filtering annotation • 836 views
ADD COMMENT
0
Entering edit mode

I emphasize: loops

ADD REPLY
0
Entering edit mode

you already used parallel Isolating and extracting regions in VCF file . So what is the problem ?

ADD REPLY
0
Entering edit mode

Yes, I made a loop with grep for extraction of particular rsID. It was okay, but I need a more convinient tool, if it exists

ADD REPLY
0
Entering edit mode

Excel or any spreadsheet software? VCF is essentially a tab separated file. This is not advisable because then you have to recreate the vcf file after filtering. Use a dedicated tool, vcftools or vcfR similar.

ADD REPLY
0
Entering edit mode

Do you mean vcftools can recreate vcf from txt after filtering?

ADD REPLY
1
Entering edit mode
10 months ago

You want a variant browser. Most GUIs are not designed to filter hundreds of samples and thousands of variants simultaneously. If you have no money and no engineering support, your choices are pretty limited.

The most mature open source variant browser is seqr. It's used by several medical schools. If you are having trouble with Docker then Seqr will likely be too difficult for you to install, as it requires several services to run.

ADD COMMENT

Login before adding your answer.

Traffic: 2392 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6