Seeking Advice on Compiling a List of Internalizing Receptors in Humans or Mice
I am currently working on a research project that aims to comprehensively catalog the repertoire of cell surface receptors that undergo regulated internalization (endocytosis) in human or mouse model systems. The ability of certain receptors to internalize from the plasma membrane into intracellular vesicles represents an important mechanism for regulating their signaling activity, trafficking, and desensitization dynamics.
While I have explored some online resources like the Gene Ontology browsable listings (https://biokb.lcsb.uni.lu/entity/GO_0031623) and the Mouse Genome Informatics database (https://www.informatics.jax.org/go/term/GO:0031623), I feel that these sources may not provide an exhaustive catalog specific to receptors capable of regulated internalization.
I would greatly appreciate recommendations from the scientific community on additional authoritative resources, curated databases, or systematic approaches that could aid in compiling a comprehensive list of such internalizing receptors across human and mouse species. Guidance on leveraging tools like sequence analysis for endocytic motifs, mining protein interaction data, or literature curation strategies would be invaluable.
Developing a rigorous methodology to establish this receptor compendium is crucial for my research endeavors focused on elucidating regulatory mechanisms of receptor trafficking and signaling. I am open to suggestions from experts who have worked on similar receptor cataloging efforts or have deep knowledge of endocytosis pathways. Any insights into reliable sources or effective strategies would be immensely helpful in advancing this project.
I cannot honestly tell you I know enough to give you reliable information about this (sorry. I wish I could).
however, i do have a few ideas i think will help you ...
good luck