Calculation of λ1000 for a continuous trait
1
0
Entering edit mode
2.4 years ago
Apprentice ▴ 170

I would like to calculate λGC adjusted to a sample size of 1000 (λ1000) for a continuous trait to assess the inflation of the test statistics of GWAS. I know how to calculate λ1000 for a case-control study (a binary trait, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782358/) . But, the paper doesn't show the equation of λ1000 for a continuous trait.

Please let me know if it is possible to calculate λ1000 for a continuous trait. If it is possible, could you tell me an equation of the λ1000 for a continuous trait.

SNP GWAS inflation • 856 views
ADD COMMENT
0
Entering edit mode

Thanks for your help! Now at least I know how to get it in case-control study...

ADD REPLY
0
Entering edit mode
8 months ago
Isaac • 0

I think the calculation process may be as below: lambda1000=(lambda-1)/N*1000 +1

ADD COMMENT
0
Entering edit mode

Thank you for your advice. Please let me know if you have any papers that show the formula.

ADD REPLY

Login before adding your answer.

Traffic: 1677 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6