Data table for LOEUF loss-of-function observed/expected upper bound fraction

Question

[Shicheng Guo]

I'm seeking collaboration to create a comprehensive Excel table detailing the LOEUF (Loss-of-Function Observed/Expected Upper Bound Fraction) for each gene, a crucial metric for understanding genetic variations and their implications on health. LOEUF provides insights into genetic variability, aids in understanding disease mechanisms by identifying genes intolerant to loss-of-function mutations, and guides genetic research towards significant biological interests. Our goal is to compile this data into an easy-to-navigate Excel table to be shared on GitHub, promoting open science and collaboration. We're looking for volunteers with expertise in data analysis, genetics, bioinformatics, and Excel to join this project. This is an opportunity to contribute to a community effort in making genetic data accessible and to enhance our understanding of the human genome. If you're interested in contributing or have insights to share, please reach out. Let's collaborate to unlock the secrets of our genome together.

Take https://gnomad.broadinstitute.org/gene/ENSG00000169174 as an example, LOEUF=1.25

[Pierre Lindenbaum]

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