How can we remove a sub-pathway from a parent pathway in Reactome Database?

Question

[Muiz Khan]

Suppose, We have a parent pathway 'Autophagy' (a top-level pathway in Reactome database) which has the stable id: R-HSA-9612973.2. This pathway has three sub-pathways: Macroautophagy (R-HSA-1632852.8), Chaperone Mediated Autophagy (R-HSA-9613829.3) & Late endosomal microautophagy (R-HSA-9615710.3).

Is there any way of removing two of those sub-pathways and get the rest one? In other words, can I remove Chaperone Mediated Autophagy (R-HSA-9613829.3) & Late endosomal microautophagy (R-HSA-9615710.3) sub-pathways from Autophagy (R-HSA-9612973.2) pathway in order to get only the Macroautophagy (R-HSA-1632852.8) sub-pathway?

What will be the right thing to do that? I have only the hierarchy information and the list of genes associated with the pathways. I can remove those genes, but how can I remove the edges/connections between them? In reactome, I suppose each edge also represents reactions.

Answer 1

[NancyTLi]

I am not sure what you mean by "remove" this pathway. In ReactomeGSA, for ssgsea analysis you are able to include a list of pathways: "A comma delimited list of pathways to include in the analysis. All other pathways will be ignored." Maybe this is useful for you?

Perhaps you can provide more details & email the Reactome helpdesk for more support: [e-mail]