Mapping of OMA IDs to UniProtKB AC

Question

[george]

I would like to ask about the mapping of gene sequences in the OMA database to UniProtKB AC. I noticed that not all OMA gene sequences seem to be cross-referenced with their UniProtKB AC. For instance, the OMA ID "IDESA00020" corresponds to the UniProtKB AC "A0A0K8NVL1," but there is no cross-reference noted.

Could you please clarify why some OMA IDs are not mapped to their respective UniProtKB AC, even when the sequences are present in UniProt? Additionally, is there a method to obtain a comprehensive mapping of all OMA IDs to UniProtKB AC?

Thank you very much in advance!

[GenoMax]

is there a method to obtain a comprehensive mapping of all OMA IDs to UniProtKB AC?

Mappings are available at UniProt: https://www.uniprot.org/database/DB-0137

Answer 1

[Adrian Altenhoff]

Hi George,

there is a complete mapping between OMA IDs and UniProtKB in the download section of the OMA browser https://omabrowser.org/oma/current/ > Mapping to UniProt (https://omabrowser.org/All/oma-uniprot.txt.gz)

We try to include all the uniprot identifiers which have an exact sequence match within the same species. The case you mention seems indeed to be the identical sequence, so I would expect it to be present - but it isn't. I'm not sure why and will investigate on this. One reason could be that we changed the bacterial genomes to follow the GTDB Taxonomy.

Thanks for letting us know. Best wishes

Adrian