Human Methylation Infinum Bead - probe to gene mapping

Question

[shrutidesai0208]

Hi, I am working with TCGA pan-can data for methylation data, and am mapping the probes to gene ids. But I find many probes with one to many mapping for gene as in the examples below:

cg16159313: ABHD14A-ACY1,ACY1,ABHD14B

cg02717570: ABHD15-AS1,ANKRD13B,GIT1

cg15206330: TP53;WRAP53

I want to understand why is this so, and what can be done to get single gene mapping for each probe?

Answer 1

[Zhenyu Zhang]

overlapping genes, or probe near multiple genes. This is quite common.