WGCNA preservation analysis

Question

[michael.flower.14]

I'd like to learn how to do a preservation analysis using WGCNA modules I've generated. However, the WGCNA tutorials and data seem to be offline.

https://horvath.genetics.ucla.edu/html/CoexpressionNetwork/ModulePreservation/Tutorials

Does anyone know where I can access the tutorial and the demo data?

https://web.archive.org/web/20211130024330/https://horvath.genetics.ucla.edu/html/CoexpressionNetwork/ModulePreservation/Tutorials/HumanChimp-Data.zip

Thanks!

Answer 1

[Michael]

This seems like a model case for why we need better sustainable bioinformatics data and services. I don't know the exact background behind this, but some things are obvious:

• The original author (Horvath) no longer works for the institution (UCLA) where the project was developed,
• He's now working for a private company (Altos) founded by Jeff Bezos
• After he left, someone (possibly UCLA) deleted his group's web-space and is unable or unwilling to bring it back
• Ratz: The important documentation is essentially lost (note the package is still available via the package manager)

Possibly you can find some of it or all here:

https://bioinformatics.stackexchange.com/questions/21885/where-to-access-the-wgcna-tutorial-documents-horvath-lab-site-down/