Entering edit mode
6 months ago
Hi,
I'm trying to use PRS-CSx which requires SNP, A1, A2, Beta/OR and P value/SE. I want to use the individual study beta's instead of the random/fixed effect. Is there a way to calculate the p value/se for the individual study betas from this information?
Columns in the file:
CHR Chromosome code
BP Basepair position
SNP SNP identifier
A1 Effect allele
A2 Non-effect allele
N Number of valid studies for this SNP
P Fixed-effects meta-analysis p-value
P(R) Random-effects meta-analysis p-value
OR Fixed-effects OR estimate
OR(R) Random-effects OR estimate
Q p-value for Cochrane's Q statistic
I I^2 heterogeneity index (0-100)
F0 Individual study beta 1
F1 Individual study beta 2
F2 Individual study beta 3
F3 Individual study beta 4
F4 Individual study beta 5