dbNSFP sift scores integration
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Entering edit mode
7 months ago
atariw ▴ 10

I am planning to try dbNSFP in order to get consistent and comparable scores of protein mutation consequences. I noticed that VEP outputs four types of SIFT scores ("Deleterious", "Deleterious-low confidence", "Tolerated", "Toleraged-low confidence"). I wonder whether/how dbNSFP does take into account the "low confidence" version of these scores ? Are those ignored or integrated in different ways with respect to "Deleterious" and "Tolerated" ? I am also looking to better understand this SIFT low-confidence labelling of the scores...

Thx a lot

SIFT VEP dbNSFP • 207 views
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