Entering edit mode
5 months ago
marie.harmel
▴
10
Hello,
I'm looking for a source to corroborate something I heard. As far as I know, even if both uses different metrics, MetaBAT tends to rely more on tetranucleotide frequencies to identify bins, making it more adept at finding prokaryotes. On the other hand, CONCOCT primarily focuses on sequence coverage, making it better at identifying eukaryotes. Is this true, and what article can I use to confirm this?
(PS: I don't have access to the original CONCOCT paper: https://doi.org/10.48550/arXiv.1312.4038)
Thank you!
I know this isn't the most useful answer to your question but I know of the group that created CONCOCT and they mainly work with microbial (mainly bacterial) metagenomes and so I'm fairly certain it was designed with prokaryotes in mind! Perhaps some kind of review article has since shown it is more effective at eukaryotic binning? I haven't heard of this before but would be interested in the answer also.