How to Specify genome version (GRCh37 release 104) in VEP REST API?

Question

[gcampof]

Hello there,

I've been using the VEP command line tool to retrieve data from my variants using HGVS notation for a while. Now, I want to perform the same operations using the VEP REST API. For my local analyses, I've been using the GRCh37 genome assembly, release 104. However, I am having trouble finding the parameter to specify the genome assembly version in the VEP REST API documentation, and I need to use it to ensure consistency in my pipeline.

Does anyone know how to set the genome assembly to GRCh37 and ensure that I am using the release 104 in the VEP REST API? Here is the API endpoint I was trying to use.

Thanks in advance

Answer 1

[Louisse_Ensembl]

Hi gcampof! GRCh37 has a separate REST server (https://grch37.rest.ensembl.org/), however, it is not possible to access earlier Ensembl VEP versions. I hope this helps!

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Louisse (Ensembl Helpdesk)

[gcampof]

Thank you very much for the information. I will use the VEP Docker image version 104 instead.