Predicting ddG stability of multi-mutation protein variants

Question

[liorglic]

Is anyone aware of tools / works / algorithms for predicting protein stability following multiple mutations?

To clarify, I'm looking for a tool that would take as input a reference protein sequence and a variant of that sequence containing multiple mutations, and produce a prediction (e.g. in terms of ddG) of the stability of the variant.

There are many tools that do that for single point mutations (Rosetta, FoldX, and numerous academic publications), but I was unable to find one that can handle multiple mutations.

I understand that this is a challenging task, but are there any useful tools out there?