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This edition of the Herald was brought to you by contribution from zx8754, GenoMax, Istvan Albert, and was edited by GenoMax, Istvan Albert,
Page not available - PMC (www.ncbi.nlm.nih.gov)
As I long believed, and now here is indication others have also long recognized, the very definition of "reproduciliby" is not all that reproducible.
submitted by: Istvan Albert
x.com (twitter.com)
I skimmed the source for this article, in @natureag by Mike Snyder's lab, and I don't find any of it even remotely credible. Tons of complex correlations that are probably meaningless or just chance. No, humans don't 'age dramatically in two bursts'
submitted by: Istvan Albert
Overlooked poor-quality patient samples in sequencing data impair reproducibility of published clinically relevant datasets | Genome Biology | Full Text (genomebiology.biomedcentral.com)
From the conclusions of paper:
we demonstrate that quality imbalance between groups of samples can significantly reduce the relevance of differential genes, consequently reducing reproducibility between studies. Appropriate experimental design and analysis methods can substantially reduce the problem.
submitted by: GenoMax
The genomes of all lungfish inform on genome expansion and tetrapod evolution | Nature (dx.doi.org)
Lungfish genomes. Humans are close to these yet the genome here is 30x human one.
submitted by: GenoMax
pgsc_calc: a reproducible workflow to calculate polygenic scores — Polygenic Score (PGS) Catalog Calculator documentation (pgsc-calc.readthedocs.io)
pgsc_calc: a reproducible workflow to calculate polygenic scores
The pgsc_calc workflow makes it easy to calculate a polygenic score (PGS) using scoring files published in the Polygenic Score (PGS) Catalog 🧬 and/or custom scoring files.
submitted by: zx8754
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