How can studies compare microarray datas with rna-seq?
1
0
Entering edit mode
3 months ago
Znow ▴ 20

I would like to compare RNA-seq data from TCGA BRCA with GEO microarray. I am going to make a risk score for predicitng prognosis bases on the coefficients from a lasso-cox model multiplied by the gene expression. Most of the studies available in pubmed trains their models in TCGA RNA-seq data and tests it in GEO microarray datasets. However, they use different measures, how is it possible to compare them? Can someone please help?

RNA-seq microarray • 489 views
ADD COMMENT
0
Entering edit mode

As you mentioned, you can use TCGA as the discovery set, and use GEO as validation. The data is never mixed together during analysis, and you are simply compare the findings.

Don't mix and compare the data directly.

ADD REPLY
0
Entering edit mode
3 months ago
Nomsy • 0

You can just direct compare them, with no problems

ADD COMMENT

Login before adding your answer.

Traffic: 1858 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6