Recommended Tool for Somatic SV Discovery in Tumor-Only WES Data

Question

[George]

Hi all,

I'm currently working on an analysis using tumor-only whole exome sequencing (WES) data and am looking for a reliable tool for structural variant (SV) discovery. Ideally, I'd like to use a tool with a somatic SV detection option, similar to what Delly offers. However, I've often seen recommendations against using Delly for WES data specifically, so I'm hesitant to go that route.

Does anyone have suggestions for a tool that works well with WES data for somatic SV discovery? Any advice or experiences would be greatly appreciated! I know I am asking for too much. I don't expect the greatest accuracy, I was just wondering if there is an option.

Thanks!