Mendelian Randomization, Liftover

Question

[lag]

Hi,

I'm about to do several two-sample mendelian randomisation analysis. I'm in doubt if it is important that both exposure and outcome dataset are from the same assembly genome (hg19/hg38). Also, I'm running several MR with the same outcome data, but different exposure datasets - is it important that every analysis are on the same build or is not important as the analysis are using rsIDs?

Thank you in advance for any input to this.

Answer 1

[gianmarcoabbadessa]

I’m interested in this issue as well and generally agree—if you’re working solely with rsIDs and not using any tools that require genomic positions, it might not be necessary. However, I’m not entirely certain and would welcome insights from other experts.