How can I check if a variant affects a TFBS?

Question

[Tania]

Hi Everyone If I have a couple of variants, annotated with annovar (hg38). They clearly span a TFBS but I don't know how much they affect those TFBS. How can I check this? Thank you

Answer 1

[jared.andrews07]

Try motifbreakR, it does what you want.

[Tania]

Great, will check that, thank you very much.