Disease-Disease Association data

Question

[singhankit973]

I am working on a deep learning model for predicting disease gene associations, for that i am using disease-gene association data primarily and supplementing other information about gene as a side information, but I am facing a bottleneck that I am unable for find disease-disease associations. And for disease-disease associations looked at various databases like Disease Ontology, Human Phenotype Ontology but I am unable to understand how to get disease-disease associations from these data sources. Please help me finding disease-disease associations and if anyone has some other database in mind then please tell me.

Thanks

[Pierre Lindenbaum]

do you have an example of such disease-disease association ?

[mark.ziemann]

The HPO database is heirarchical, so you have diseases and subtypes. See this example. This structure could be used to show some connections. Also, for each HPO category, there are genes associated with that condition. You could use Jaccard similarity (or another similarity measure) of these gene sets to infer tentative disease-disease associations.