Installing VEP for a Specific Chromosome (e.g., Chromosome 1) is not possible??

Question

[Manuel]

Is there a way to install VEP for only specific chromosomes, such as chromosome 1?

I know I can install the full cache and then delete what I don’t need (at least, according to ChatGPT), but that’s not ideal for me. I need to run a GitHub Action to install VEP for a single chromosome and use it directly. I cannot install the entire database and then remove the unnecessary data.

[dthorbur]

VEP as in ensembl's Variant Effect Predictor? If so, you don't have to download any cache. You can use the slower --database flag to use an online database.

Also, why is downloading the database not ideal for you? It sounds more like you need to only annotate a single chromosome, rather than download the database for it IMO. If this is the case, you can just annotate the VCF for just that chromosome.