PAN-GO Functionome: A compendium of human gene functions derived from evolutionary modelling
GO's latest Nature paper announces the release of a brand new resource for gene function descriptions: the PAN-GO Functionome. The PAN-GO Functionome is the set of all annotated functional characteristics ("Gene Ontology annotations") for human protein-coding genes, as determined by the PAN-GO (Phylogenetic ANnotation using Gene Ontology) project, a collaboration between the Gene Ontology Consortium and the PANTHER evolutionary tree resource. Note this is not just Molecular Function terms; the Functionome also includes all known Biological Process and Cellular Component info. The PAN-GO Functionome uses large-scale evolutionary models to combine data from other well-studied organisms, resulting in an incredibly accurate and comprehensive resource for the functions of human genes. Analyses performed using the PAN-GO Functionome, available at functionome.geneontology.org, are even more informative than those based only on traditional GO annotations- which have been the gold standard for over 25 years.
Additionally, the PAN-GO Functionome invites and encourages all researchers of any level to provide immediate feedback. If you find a gene that is not annotated but you know of research that describes it, you find errors or omissions in the data, or any other concerns, you can instantly request the data to be amended using the feedback link on the PAN-GO Functionome homepage.
GO has tutorials for:
- Finding functions for a selected human gene in the Functionome
- Finding genes in a selected "Function Category" (GO Subset term) in the Functionome
- coming soon: Finding genes with unknown functions in the Functionome
- coming soon: Performing an Enrichment Analysis for a list of human genes, using PAN-GO annotations
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