How to make amazing UMAP to spatialPlot GIF

Question

[noodlejackson]

Hi everyone,

Any clues how to make this amazing gif which transitions from UMAP to spatial dimplot or similar. Link to the gif is here, otherwise see screenshots below:

https://crukscotlandinstitute.b-cdn.net/images/stories/beatson_research_group/DasGupta/image001.gif

Answer 1

[LChart]

Looks to me to be a sequence of intermediate linear interpolations. For each point you have coordinates (U1, U2) for the UMAP plot, (S1, S2) for the spatial plot. Define:

X_i(t) = t * U_i + (1-t) * S_i

for t = 0, 0.05, 0.1, ..., 0.95, 1.0

Create 21 images.

In python use the pillow library to open the images and create a gif, e.g.

frames = [Image.open(f'imagename_{j}' for j in range(21)]
frames[0].save('output.gif', format='GIF', append_images=frames[1:], save_all=True, duration=30, loop=0)

[noodlejackson]

Thank you @LChart, wow that sounds like a very elegant solution! I've got the seurat currently in R. I'll export to python and give it a bash.