Can somebody suggest me tools for insilico analysis of intronic and neargene SNP's effects on gene expression or protein structure just like SIFT, PolyPhen for missense SNPs
Can somebody suggest me tools for insilico analysis of intronic and neargene SNP's effects on gene expression or protein structure just like SIFT, PolyPhen for missense SNPs
As far as I know there is no good way to do this yet. My best advice is to use conservation scores; PhastCons and GERP are the two I'm familiar with. You can also limit your search to SNP's that fall in regulatory features, as defined by Ensembl, but I would start by looking at SNPs that fall in highly conserved regions.
A relevant biostar post
GTEx - You can look in their dataset if your SNP is associated with the expression levels of any gene in various tissues: http://www.gtexportal.org/home/#
CADD - "CADD is a tool for scoring the deleteriousness of single nucleotide variants as well as insertion/deletions variants in the human genome.": http://cadd.gs.washington.edu/
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