Entering edit mode
3.7 years ago
feng920308
•
0
The "Biostar-handbook" says trim data to borders is good.
"As we mentioned this before ChIP-Seq data in general and ChIP-Exo in particular measures the left-right borders of the binding sites rather than the center of them. Even though tools should be able to reconstruct these borders algorithmically from the entire alignments, sometimes (often) it is best to not even "show" this spurious data to the algorithm, and to keep only the essential sections of the data, in this case, the borders only"
However, many protocols did not show this step, even in the later chapter of this book.
Therefore, I want to know trim data to borders still necessary?
